Registration Dossier
Registration Dossier
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EC number: 821-185-1 | CAS number: 1777721-63-7
Oxidising properties
Administrative data
- Endpoint:
- oxidising solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 November 2016 - 18 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test O.1 (Test for oxidizing solids)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.17 (Oxidising Properties (Solids))
- GLP compliance:
- yes
Test material
- Reference substance name:
- (2S,3S)-3-({5-fluoro-2-[5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)bicyclo[2.2.2]octane-2-carboxylic acid
- EC Number:
- 821-185-1
- Cas Number:
- 1777721-63-7
- Molecular formula:
- C27H25F2N5O4S
- IUPAC Name:
- (2S,3S)-3-({5-fluoro-2-[5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)bicyclo[2.2.2]octane-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of the test material (as cited in study reports): JNJ-63757109-AAA (T003690)
- Physical state: solid (powder)
- Appearance: white to slightly yellow power
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I16BD1072
- Analytical purity: 100 %
- Expiration date: 04 March 2018
- Storage condition: at room temperature
Study design
- Contact with:
- powdered cellulose
- Duration of test (contact time):
- 63 h
Results and discussion
Test results (Oxidising solids)open allclose all
- Key result
- Sample tested:
- 1:1 sample-to-cellulose ratio
- Parameter:
- mean burning time
- Result:
- > 180 s
- Key result
- Sample tested:
- 4:1 sample-to-cellulose ratio
- Parameter:
- mean burning time
- Result:
- > 180 s
- Sample tested:
- reference: 3:7 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 91 s
- Sample tested:
- reference: 2:3 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 48 s
- Sample tested:
- reference: 3:2 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 16 s
Any other information on results incl. tables
Burning rates of test item / cellulose mixtures
| Test item/cellulose (w/w) | Burning time [s] | Mean burning time [s] |
| 4:1 | >180 | >180 |
| >180 | ||
| >180 | ||
| >180 | ||
| >180 | ||
| 1:1 | >180 | >180 |
| >180 | ||
| >180 | ||
| >180 | ||
| >180 |
Burning rates of potassium bromate / cellulose mixtures
| Potassium bromate/cellulose (w/w) | Mean burning time [s] |
| 3:7 | 91 |
| 2:3 | 48 |
| 3:2 | 16 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not oxidizing
- Conclusions:
- The full test was performed to monitor the oxidizing properties of JNJ-63757109-AAA (T003690). Based on the results obtained it was concluded that the test item has no oxidizing properties and is therefore not classified as a Division 5.1 substance.
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