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EC number: 220-278-9 | CAS number: 2698-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [(2-chlorophenyl)methylene]malononitrile
- EC Number:
- 220-278-9
- EC Name:
- [(2-chlorophenyl)methylene]malononitrile
- Cas Number:
- 2698-41-1
- Molecular formula:
- C10H5ClN2
- IUPAC Name:
- [(2-chlorophenyl)methylene]malononitrile
- Reference substance name:
- 4-methylpentan-2-one
- EC Number:
- 203-550-1
- EC Name:
- 4-methylpentan-2-one
- Cas Number:
- 108-10-1
- Molecular formula:
- C6H12O
- IUPAC Name:
- 4-methylpentan-2-one
- Reference substance name:
- hexyl acetate
- Cas Number:
- 88230-35-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- hexyl acetate
- Reference substance name:
- Dimethyl glutarate
- EC Number:
- 214-277-2
- EC Name:
- Dimethyl glutarate
- Cas Number:
- 1119-40-0
- Molecular formula:
- C7H12O4
- IUPAC Name:
- dimethyl glutarate
- Reference substance name:
- unknown impurities
- Cas Number:
- Not applicable
- Molecular formula:
- Not applicable
- IUPAC Name:
- unknown impurities
Constituent 1
Constituent 2
Constituent 3
Constituent 4
impurity 1
- Specific details on test material used for the study:
- Not specified
Test animals / tissue source
- Species:
- cattle
- Strain:
- not specified
Test system
- Vehicle:
- other: Dimethyl glutarate, Hexyl acetate or MIBK
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 5% in dimethyl glutarate
- Value:
- ca. 6.7
- Vehicle controls validity:
- not examined
- Remarks:
- "corrected values"
- Negative controls validity:
- valid
- Remarks:
- 0,9% sodium chloride score 2.1 mild irritant
- Positive controls validity:
- valid
- Remarks:
- absolute ethanol score 53 moderate irritant
- Remarks on result:
- positive indication of irritation
- Remarks:
- mean score on 3 corneas per vehicule
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 5% in hexyl acetate
- Value:
- ca. 2.6
- Vehicle controls validity:
- not specified
- Remarks:
- idem
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Remarks:
- idem
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 5% in methyl isobutyl ketone
- Value:
- ca. 11.5
- Vehicle controls validity:
- not specified
- Negative controls validity:
- valid
- Remarks:
- idem
- Positive controls validity:
- valid
- Remarks:
- idem
- Remarks on result:
- positive indication of irritation
- Other effects / acceptance of results:
- Quality criteria required for acceptance of results in the test were satisfied
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Conclusions:
- 5% solutions of CS in dimethyl glutarate, hexyl acetate and MIBK were mild-irritants for the eyes (in vitro irritation score of 2.6 to 11.5, whereas positive control ethanol is 53).
- Executive summary:
According to a BCOP assay following OECD 437 methodology, the results showed that 5% solutions of CS in dimethyl glutarate, hexyl acetate and MIBK were mild-irritants for the eyes (in vitro irritation score of 2.6 to 11.5, whereas positive control ethanol is 53). This result is published in (Croft, 2003).
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