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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
Neomenthol
Author:
World Health Organization
Year:
1999
Bibliographic source:
World Health Organization

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of (+)-Neomenthol (CAS no: 2216-52-6) in mice.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(+)-neomenthol
EC Number:
218-691-4
EC Name:
(+)-neomenthol
Cas Number:
2216-52-6
Molecular formula:
C10H20O
IUPAC Name:
(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol
Details on test material:
- IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic
Specific details on test material used for the study:
- IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
4000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed in treated mice.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be 4000 mg/kg bw, when mice were treated with (+)-Neomenthol (CAS no: 2216-52-6) via oral route.
Executive summary:

Acute oral toxicity study of (+)-Neomenthol (CAS no: 2216-52-6) was conducted in mice at the dose concentration of 4000 mg/kg bw. 50% mortality was observed in treated mice. Hence, LD50 value was considered to be 4000 mg/kg bw, when mice were treated with(+)-Neomentholvia oral route.