Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-048-3 | CAS number: 3327-22-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Method: other: Draft OECD Guideline 428 skin absorption in vitro method
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- EC Number:
- 222-048-3
- EC Name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- Cas Number:
- 3327-22-8
- Molecular formula:
- C6H15ClNO.Cl
- IUPAC Name:
- 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- 48 hour(s)
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
Concentration: 65%, dose 7028 µg/cm2
Flux constant [µg cm-2 h-1]: 18.5 ± 13.0
Kp-value [cm h-1]: 0.026 ± 0.018
Lag time [h]: 0.1 ± 0.2
Relative skin absorption after 48 h: 13.9%
Concentration: 20%, dose 1966 µg/cm2
Flux constant [µg cm-2 h-1]: 21.0 ± 13.6
Kp-value [cm h-1]: 0.107 ± 0.069 Lag time [h]: 0.2 ± 0.4
Relative skin absorption after 48 h: 40.9%
Concentration: 1%, dose 94.6 µg/cm2
Flux constant [µg cm-2 h-1]: 0.61 ± 0.7
Kp-value [cm h-1]: 0.065 ± 0.074
Lag time [h]: 1.8 ± 0.4
Relative skin absorption after 48 h: 22.6%
Concentration: 0.1%, dose 9.73 µg/cm2
Flux constant [µg cm-2 h-1]: 0.15 ± 0.12
Kp-value [cm h-1]: 0.151 ± 0.128
Lag time [h]: 1.3 ± 0.6
Relative skin absorption after 48 h: 43.6%
The amount of radioactivity on the skin after stripping was 5.3 to 17.6-fold lower than the amount of radioactivity in the receptor fluid. The mean recovery of radioactivity was between 91.2 and 102.2 %.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
