Registration Dossier
Registration Dossier
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EC number: 243-020-7 | CAS number: 19395-41-6
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Title:
- ECOSAR (US EPA)
- Year:
- 2 017
- Bibliographic source:
- ECOSAR (US EPA) Version 2.0
Materials and methods
- Principles of method if other than guideline:
- - Software tool(s) used including version:
ECOSAR Version 2.0 was released 2017
- Model(s) used: ECOlogical Structure-Activity Relationship Model (ECOSAR)
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- no
Test material
- Reference substance name:
- α-phenylpiperidine-2-acetic acid
- EC Number:
- 243-020-7
- EC Name:
- α-phenylpiperidine-2-acetic acid
- Cas Number:
- 19395-41-6
- Molecular formula:
- C13H17NO2
- IUPAC Name:
- α-phenylpiperidine-2-acetic acid
- Test material form:
- solid: granular
Constituent 1
- Specific details on test material used for the study:
- C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3 662.66 mg/L
- Remarks on result:
- other:
- Remarks:
- *estimated water solubility 21022.54 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The prediction is adequate for the Classification and Labelling or risk assessment of the substance as indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3. The predictions do not indicate extreme or acute toxicities relevant for classification and labelling. The assessment indicates that the prediction is suitable for the regulatory conclusion in accordance with the tonnage driven information requirements.
Aliphatic Amines SAR: Daphnid 48-hr LC50 = 3662.66 mg/L*
*estimated water solubility 21022.54 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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