Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted in accordance xith the following guidelines :
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method -13 April 2004)
- EU Method A.8 'partition Coefficient' published 31 May 2008

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
White powder
Specific details on test material used for the study:
Batch 562371/016

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
ca. 2.162
Temp.:
25 °C
pH:
ca. 6
Details on results:
The chromatogram of the test item gave one peak at 4.424min. With the calibration function log K versus log Pow, the corresponding log Pow was determined as 2.162 +/- 0.009. This value is the mean +/- standard deviation of three independant determinations

Applicant's summary and conclusion

Conclusions:
Using the correlation log K/log Pow, the log Pow of the test item 1574 ACIDE was determined as 2.162 +/- 0.009.
Executive summary:

The chromatogram of the test item gave one peak at 4.424min. With the calibration function log K versus log Pow, the corresponding log Pow was determined as 2.162 +/- 0.009. This value is the mean +/- standard deviation of three independant determinations