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EC number: 201-818-2 | CAS number: 88-30-2
Stability in organic solvents and identity of relevant degradation products
Administrative data
Link to relevant study record(s)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- from 1999-04-16 to 2000-03-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EEC-guideline 92/69/EWG A.6, Flask-method
- Deviations:
- no
- GLP compliance:
- yes
- Test substance stable:
- yes
- Transformation products:
- not measured
- Conclusions:
- The n-hexane solubility of the test item as mean of the measured values of flasks two and three was: n-hexane solubility (20 °C) = 177.1 ± 1.3 mg/L. In methanol, n-octanol and acetone, the test item is completely miscible in all ratio.
- Executive summary:
The solubility of the test item in organic solvents at 20 °C was determined following the EEC-guideline 92/69/EWG A.6, Flask-method. The following solubilities were determined:
- in methanol - miscible
- in acetone - miscible
- in n-octanol - miscible
- in n-hexane - 0.117 g/L = 177.1 mg/L.
Reference
Results of the Modified Addition Method
Solvent |
Mean measured solubility [g/L] |
Methanol |
miscible |
Aceton |
miscible |
n-Octanol |
miscible |
The test substance was miscible in all ratio with the above mentioned solvents.
Results of the Shake Flask method
The water solubility increased with the time of equilibration. Therefore only the measured results from flask 2 and flask 3 were used to calculate the n-hexane solubility of the test substance.
Flask |
Dilution factor |
Measured peak area 1st injection [µV*s] |
Measured peak area 2nd injection [µV*s] |
Mean measured peak area [µV*s] |
Measured water solubility [g/L] |
1 |
1 1 |
2766851 2741600 |
2752085 2779113 |
2759468.0 2760356.5 |
130.21 130.25 |
2 |
1 1 |
3715422 3724352 |
3730084 3744078 |
3722753.0 3734215.0 |
175.75 176.29 |
3 |
1 1 |
3783622 3778666 |
3773325 3763706 |
3778473.5 3771186.0 |
178.38 178.04 |
The n-hexane solubility of the test item as mean of the measured values of flasks two and three was:
n-hexane solubility (20 °C) = 177.1 ± 1.3 mg/L
Description of key information
The n-hexane solubility of the test item as mean of the measured values of flasks two and three was: n-hexane solubility (20 °C) = 177.1 ± 1.3 mg/L. In methanol, n-octanol and acetone, the test item is completely miscible in all ratio.
Additional information
The solubility of the test item in organic solvents at 20 °C was determined following the EEC-guideline 92/69/EWG A.6, Flask-method. The following solubilities were determined:
- in methanol - miscible
- in acetone - miscible
- in n-octanol - miscible
- in n-hexan - 0.117 g/L = 177.1 mg/L.
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