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Physical & Chemical properties

Partition coefficient

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Description of key information

Under the conditions of this study the test material displayed a weight-averaged log Kow of 6.27 at neutral pH.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.27
at the temperature of:
23 °C

Additional information

The partition coefficient of the test material was determined in accordance with the standardised guideline OECD 117 under GLP conditions using the HPLC method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

A method development run under standard OECD 117 conditions (methanol:water (75:25)) did not yield a useful chromatogram as the test material retained surfactant qualities and did not interact properly with the column. Increasing the methanol content to 90% negated the test material’s surfactant qualities. It was determined that by running the test material in a high methanolic mobile phase, methanol:water (90:10), a chromatogram could be obtained with two, well resolved main peaks. The calibration standards provided a useable calibration curve under these conditions.

The test material was composed of several components, displayed as many peaks, ranging in retention time from approximately 1.9 to 11 minutes. Only peaks with an area greater than 5% of the total were included in the calculations of Kow. The error in the measurements was estimated using the relative percent difference (RPD) of the two independent preparations analysed in these experiments. The difference between the two preparations was 0.05 log units, corresponding to 0.85% RPD for neutral pH.

Under the conditions of this study the test material displayed a weight-averaged log Kow of 6.27 at neutral pH.