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Registration Dossier
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EC number: 211-189-6 | CAS number: 632-99-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- The data was from safety assesment report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Environment and Quality of Life - Reports (Seventh Series)- Basic violet 14
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 988
- Bibliographic source:
- Environment and Quality of Life - Reports (Seventh Series)- Basic violet 14 European Commission (EC) - Scientific Committee on Cosmetology (SCC) 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mention below
- Principles of method if other than guideline:
- To evaluate the skin irritation potential for ((4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride) on Rabbit
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride)
- Cas Number:
- 632-99-5
- Molecular formula:
- C20H19N3.ClH
- IUPAC Name:
- (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride)
- Details on test material:
- IUPAC name:((4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride)
commen name : Basic violet 14
Molecular formula :C20H19N3.ClH
molecular weight: 337.8 g/mol
InChI:1S/C20H19N3.ClH/c1-13-12-16(6-11-19(13)23)20(14-2-7-17(21)8-3-14)15-4-9-18(22)10-5-15;/h2-12,21H,22-23H2,1H3;1H/b20-14-,21-17?
Smiles:C(\c1cc(c(N)cc1)C)(c1ccc(N)cc1)=C1/C=CC(=N)C=C1.Cl
Constituent 1
- Specific details on test material used for the study:
- IUPAC name:((4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride)
commen name : Basic violet 14
Molecular formula :C20H19N3.ClH
molecular weight: 337.8 g/mol
InChI:1S/C20H19N3.ClH/c1-13-12-16(6-11-19(13)23)20(14-2-7-17(21)8-3-14)15-4-9-18(22)10-5-15;/h2-12,21H,22-23H2,1H3;1H/b20-14-,21-17?
Smiles:C(\c1cc(c(N)cc1)C)(c1ccc(N)cc1)=C1/C=CC(=N)C=C1.Cl
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: Propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- 0.5% in Propylene glycol
- Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Basic Violet 14 did not produce edema and no microscopic changes were observed on the treated skin sites.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- Basic violet 14 when topically applied on rabbit skin produced no skin reaction.
Hence, Basic Violet 14 can be considered to be not irritating to skin. - Executive summary:
Skin irritation test was performed on rabbits to assess the irritation potential of Basic Violet 14. 0.5% Basci violet 14 in Propylene glycol was applied to the skin of rabbits and observed for signs of irritation (duration and number of animals not mentioned).
Basic Violet 14 did not produce edema and no microscopic changes were observed on the treated skin sites.
Hence, Basic Violet 14 can be considered to be not irritating to skin.
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