Registration Dossier
Registration Dossier
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EC number: 235-795-5 | CAS number: 12738-64-6
Endpoint summary
Administrative data
Description of key information
The substance has a high molecular weight and cannot cross biological membranes. It is therefore concluded that the substance will not be acutely toxic to fish and invertebrates and algae at and below water solubility. Furthermore the QSAR (ECOSAR) estimated aquatic toxicity lies far above the estimated and measured water solubility.
The toxicity to algae and microorganism are based on read-across to benzoic acid.The sucrose molecule itself is on annex IV in the REACH regulation and does need to be REACH registered due to its low hazard. Therefore, any toxic activity of sucrose benzoate should be associated with the benzoate groups. Based on the very conservative assumption that each mole benzoate in sucrose benzoate has the same toxicity to algae and microorganism as one mole free benzoic acid. It is to be noted that the hereby derived E(L)C50 values for algae and microorganism are far above the water solubility of sucrose benzoate.
Additional information
The water solubility of Sucrose benzoate was determined by flask method according to OECD test guideline 105. The water solubility of Sucrose benzoate was determined after four days to be 3 mg/L at 20 °C.
The water solubility is dependent on the numbers of benzoate groups attached. A high number of benzoate groups will increase the toxicity compared to only a few groups (1-2) attached.
The study which was conducted according to OECD guideline 105 is believed to have been conducted with sucrose benzoate with a variant number of benzoate groups attached.
QSAR was calculated based on smiles notation
SMILES : c0ccc(cc0)C(=O)OCC2C(C(C(C(O2)OC3(C(C(C(O3)COC(=O)c4ccccc4)OC(=O)c5ccccc5)OC(=O)c6ccccc6)COC(=O)c7ccccc7)OC(=O)c8ccccc8)OC(=O)c9ccccc9)OC(=O)c1ccccc1
The QSAR (ECOSAR) estimated aquatic toxicity lies far above the estimated and measured water solubility. Furthermore the substance has a high molecular weight and cannot cross biological membranes. It is therefore concluded that the substance will not be acutely toxic to fish, invertebrates and algae at and below water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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