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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
April 13, 2004
Qualifier:
according to guideline
Guideline:
other: Guidelines for the testing of Chemicals, Section 2.8, Hydrolysis as a Function of pH (Public Notice No. 2017-4, issued by the National Institute of Environmental Research, Republic of Korea on March 14, 2017).
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Identity MIRAMER SB
KIT Code No. K-6893
CAS No. 12738-64-6
Batch/Lot No. 161228BO5
Appearance Flake
Purity 100.0%
Storage conditions Room temperature
Expiry date December 27, 2017
Details on test conditions:
Test duration : 5 days
Measured test temperature : 50.3±0.1˚C (min. 50.2˚C, max. 50.3˚C during the test)
Light and oxygen : Dark, Exclusion of oxygen
Test concentration : 10 mg/L (ca. 0.000009 M)
Duration:
5 d
pH:
4
Temp.:
50.3 °C
Initial conc. measured:
10 mg/L
Duration:
5 d
pH:
7
Temp.:
50.3 °C
Initial conc. measured:
10 mg/L
Duration:
5 d
pH:
9
Temp.:
50.3 °C
Initial conc. measured:
10 mg/L
Number of replicates:
duplicate
Preliminary study:
The percentage hydrolysis of test item was calculated as negative value at pH 4.0, 7.0 and pH 9.0 after 5 days
Transformation products:
not specified
Remarks:
No information on transformation products (no hydrolysis)
Details on hydrolysis and appearance of transformation product(s):
No information on transformation products (no hydrolysis)
Key result
pH:
4
Temp.:
50.3 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Key result
pH:
7
Temp.:
50.3 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Key result
pH:
9
Temp.:
50.3 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Validity criteria fulfilled:
not specified
Conclusions:
MIRAMER SB was considered hydrolytically stable (t0.5, 25˚C >1year) in acidic /alkaline / neutral conditions.
Executive summary:

Hydrolysis of MIRAMER SB was performed in compliance with following the OECD Guideline No. 111: and Guidelines for the testing of chemicals, Section 2.8, Hydrolysis as a Function

of pH.

At preliminary test (Tier I), the percentage hydrolysis of the MIRAMER SB were negative values at pH 4.0 7.0 and 9.0, respectively, indicating that no degradation was observed between 0 and 5

days at each buffer solution during the 50˚C study. MIRAMER SB was considered hydrolytically stable (t0.5, 25˚C >1year) in acidic /alkaline / neutral conditions.

Description of key information

The percentage hydrolysis of test item was found as negative value at pH 4.0, 7.0 and pH 9.0 after 5 days

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
50.3 °C

Additional information

The percentage hydrolysis of test item was found as negative value at pH 4.0, 7.0 and pH 9.0 after 5 days