Registration Dossier
Registration Dossier
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EC number: 250-426-8 | CAS number: 31001-77-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to algae: 72 hour ErC50 931 mg/l (nominal) (exceeds highest concentration tested) (EU method C.3), read-across from an analogous substance, 3-trimethoxysilylpropane-1-thiol (CAS 4420-74-0). The ErC50 is equivalent to 731 mg/l, ErC10 is equivalent to 72 mg/l and NOErC equivalent to 31 mg/l when expressed in terms of 3-(trihydroxysilyl)propanethiol.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 731 mg/L
- EC10 or NOEC for freshwater algae:
- 72 mg/L
Additional information
There are no reliable algal inhibition data available for 3-[dimethoxy(methyl)silyl]propanethiol (CAS 31001-77-1), therefore good quality data for an appropriate structural analogue, 3-trimethoxysilylpropane-1-thiol (CAS 4420-74-0), have been read across. Both substances have structurally similar silanol hydrolysis products, 3-(dihydroxymethylsilyl)propanethiol and 3- (trihydroxysilyl)propanethiol respectively. The other hydrolysis product is methanol in both cases.
A 72-h ErC50 value of 931 mg/l, ErC10 of 92 mg/l and a NOErC of 40 mg/l (nominal) have been determined for the effects of 3-trimethoxysilylpropane-1-thiol (CAS 4420-74-0) on growth rate of Scenedesmus subspicatus (new name: Desmodesmus subspicatus). In view of the test media preparation method and exposure regime it is likely that the test organisms were exposed primarily to the hydrolysis products of the tested substance. The ErC50 is therefore equivalent to 731 mg/l, ErC10 72 mg/l and NOErC 31 mg/l when expressed in terms of 3-(trihydroxysilyl)propanethiol.
Refer to the discussion in the Section 6 endpoint summary or further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
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