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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

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Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data estimated by the QSAR Toolbox.
GLP compliance:
no
Test organisms (species):
other: Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum) Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata)
Test type:
not specified
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
2.05 mg/L
Basis for effect:
growth rate
Remarks on result:
other: Toolbox value by read-across
Conclusions:
The algae toxicity of 1,3-difluorobenzene was determined by read-across using the QSAR Toolbox and the 96h - EC50 - growth rate was 2.05 mg/L.
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data estimated by the QSAR Toolbox.
GLP compliance:
no
Test organisms (species):
other: Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum) Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata)
Test type:
not specified
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
9.16 mg/L
Basis for effect:
growth rate
Remarks on result:
other: Toolbox value by trend analysis
Conclusions:
The algae toxicity of 1,3-difluorobenzene was determined by trend analysis using the QSAR Toolbox and the 96h - EC50 - growth rate was 9.16 mg/L.

Description of key information

Two predictions were performed with QSAR Toolbox, one by read-across (96h EC50: 2.05 mg/L), one by trend analysis (96h EC50: 9.16 mg/L).

Both estimations provide the same conclusion, i.e. 1,3 -difluorobenzene is considered as toxic to algae. As a worst case approach, the lowest predicted EC50 value is considered for the assessment of the substance.

Key value for chemical safety assessment

EC50 for freshwater algae:
2.05 mg/L

Additional information