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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data estimated by the QSAR Toolbox.
GLP compliance:
no
Test organisms (species):
other: Ceriodaphnia dubia Daphnia magna
Test type:
not specified
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.07 mg/L
Basis for effect:
other: Intoxication
Remarks on result:
other: Toolbox value by read-across
Conclusions:
The daphnia toxicity of 1,3-difluorobenzene was determined by read-across using the QSAR Toolbox and the 48h - EC50 - intoxication was 2.07 mg/L.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data estimated by the QSAR Toolbox
GLP compliance:
no
Test organisms (species):
other: Ceriodaphnia dubia Daphnia magna
Test type:
not specified
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
4.73 mg/L
Basis for effect:
other: intoxication
Remarks on result:
other: Toolbox value by trend analysis
Conclusions:
The daphnia toxicity of 1,3-difluorobenzene was determined by trend analysis using the QSAR Toolbox and the 48h - EC50 - intoxication was 4.73 mg/L.

Description of key information

Two predictions were performed with QSAR Toolbox, one by read-across (48h EC50: 2.07 mg/L), one by trend analysis (48h EC50: 4.73 mg/L).

Both estimations provide the same conclusion, i.e. 1,3 -difluorobenzene is considered as toxic to aquatic invertebrates. As a worst case approach, the lowest predicted EC50 value is considered for the assessment of the substance.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.07 mg/L

Additional information