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Diss Factsheets
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EC number: 204-340-2 | CAS number: 119-64-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-04-10 to 1995-04-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: Dissolved oxygen found low in several solutions; solvent concentration exceeds recommended concentration
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Cited as Directive 92/69/EEC, C.1
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- The test item concentration was measured before the start of the study (0 h)
The analysis of one additional replicate per concentration level was repeated after 24 hours (parallel sample without fish) - Vehicle:
- yes
- Details on test solutions:
- - Vehicle, solvent: 10 g test substance/L ethanol (abs.)
- Maximum concentration of vehicle/ solvent: 1.4 ml ethanol/L - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Supplier: West Aquarium, Bad Lauterberg (Germany)
- Wild caught: no - Age/size/weight/loading: 3 cm +/- 0.5 cm
- Feeding: daily 1 % of body weight TetraMin
- Pretreatment: Three times per week treatment with malachite green followed by 14 days under quarantine
- Feeding during test: no - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- ca. 12 degree dH
- Test temperature:
- 20 degree °C (constant)
- pH:
- 7.7 - 8.0 (no adjustment of pH)
- Dissolved oxygen:
- 13 - 102 % saturation.
- Nominal and measured concentrations:
- 3.5, 5.0, 7.0, 10, 14 mg/l (nominal)
1.5, 2.4, 3.7, 9.1, 7.9 mg/l (geometric mean of two analyses):
(1) 1.9, 2.8, 5.4, 9.8, 9.9 mg/l (beginning of test)
(2) 1.2, 2.1, 2.6, 8.4, 6.3 mg/l (stability control)
The geometric mean analytical concentrations were used for the evaluation. - Details on test conditions:
- - Dilution water: tap water (Gelsenwasser AG)
- Aeration: no (test vessels covered)
- Renewal of test solution: daily, freshly prepared
- Exposure vessel type: ca. 20 l aquarium with 10 l test solution
- Number of replicates, fish per replicate: 1, 10
- Photoperiod: 16 hours light / 8 hours dark - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 2.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: CL 2.4-3.7
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 9.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: not available
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 3.7-7.9
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 2.4-3.7
- Details on results:
- Control: 0 % dead
Solvent: 0 % dead
A: 1.5 mg/l: 0 % dead
B: 2.4 mg/l: 0 % dead
C: 3.7 mg/l: 80 % dead (6 died on day 3, 2 on day 4)
D: 9.1 mg/l: 100 % dead (all fish died on day 2)
E: 7.9 mg/l: 100 % dead (all fish died on day 2)
The results are based on the geometrical means (0 and 24 h) of the meassured concentrations - Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 was determined as 3.2 mg/L indicating that the test item may be toxic to fish.
- Executive summary:
Brachydanio rerio, were exposed to tetrahydronaphthalene at nominal concentrations ranging from 3.5 to 14 mg/l under static conditions for a period of 96 hours according to EU method C.1. The following endpoint was derived:
LC50: 3.2 mg/L
Endpoint(s) monitored: mortalityThe study was classified as "reliable with restrictions".
Reference
Description of key information
The aquatic effects of Tetrahydronaphthalene on fish were tested in a 96h semi-static study with Brachydanio rerio according to Directive 92/96/ECC, C.1. (Scholz, 1995). A series of 5 concentrations were tested: 3.5, 5.0, 7.0, 10 and 14 mg/L (geometric mean of two analysis after 0 and 24 hours: 1.5, 2.4, 3.7, 9.1 and 7.9 mg/L ). The results are based on the geometrical means of the test concentrations measured at 0 and 24 h since the test item concentration deviated by more than 20% after 24 hours. The LC50(96h) was determined to be 3.2 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.2 mg/L
Additional information
The lowest LC50 value of 3.2 mg/L was estimated after 96h by graphical / visual evaluation. The LC0 (equivalent to NOEC) was determined as 2.4 mg/l and the LC100 as 7.9 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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