Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-201-1 | CAS number: 25711-72-2
Endpoint summary
Administrative data
Description of key information
Adsorption/desorption
KOCWIN model (v2.00) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the soil adsorption coefficient i.e Koc value of test chemical
1-(3-aminophenyl)urea (CAS No. 25711 -72 -2). The soil adsorption coefficient i.e Koc value of 1-(3-aminophenyl)urea was estimated to be 17.87 L/kg (log Koc= 1.2521) by means of MCI method (at 25 deg C). This Koc value indicates that the substance 1-(3-aminophenyl)urea has a negligible sorption to soil and sediment and therefore have rapid migration to ground water.
Additional information
Adsorption/desorption
Various predicted data for the target compound 1-(3-aminophenyl)urea(CAS No. 25711-72-2) were reviewed for the adsorption end point which are summarized as below:
Using the KOCWIN Program (v2.00) of Estimation Programs Interface (EPI Suite, 2017) the soil adsorption coefficient i.e Koc value of test chemical 1-(3-aminophenyl)urea (CAS No. 25711 -72 -2) was predicted. The soil adsorption coefficient i.e Koc value of 1-(3-aminophenyl)urea was estimated to be 17.87 L/kg (log Koc= 1.2521) by means of MCI method (at 25 deg C).
The Soil Adsorption Coefficient i.e Koc value of test substance 1-(3-aminophenyl)urea was estimated using Adsorption Coefficient module (v12.1.0.50374) program at pH 0-3, 4, 5, 6, 7-10, 11, 12, 13 and 14 as Koc approx. 1, 3.96, 12.3, 15.6, 16.1, 16.0, 15.0, 9.19 and 2.00, respectively (Log Koc ranges from 0.3 ± 1.0 to 1.2 ± 1.0) (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017).
In an another prediction done by using ChemSpider Database (2017), the Soil Adsorption Coefficient i.e Koc value of test substance 1-(3-aminophenyl)urea (CAS no. 25711 -72 -2) was estimated to be 20.76 (log Koc = 1.317) and 22.76 (log Koc = 1.357) at pH 5.5 and 7.4, respectively.
Additional soil adsorption coefficient i.e Koc value of test chemical 1 -(3 -aminophenyl)urea (CAS No. 25711 -72 -2) was estimated using the SciFinder database (American Chemical Society (ACS), 2017). The soil adsorption coefficient i.e Koc value of 1 -(3 -aminophenyl)urea was estimated to be 1.0, 4.55, 14.1, 17.9, 18.4 and 18.5 at pH 1 -3, 4, 5, 6, 7 and 8 -10 (at 25 deg C), respectively.
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the adsorption coefficient i.e KOC for test substance 1 -(3 -aminophenyl) urea was estimated to be 31.9 L/kg (log Koc = 1.503) .The predicted KOC result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 1-(3-aminophenyl)urea is mobile in soil.
On the basis of above results for target chemical 1-(3-aminophenyl)urea (from EPI suite, ACD labs,ChemSpider, SciFinder database and CompTox Chemistry Dashboard,2017), it can be concluded that the Koc value of test substance 1-(3-aminophenyl)urea ranges from 1 – 31.9 indicating that the test chemical has a negligible sorption to soil and sediment and therefore have a rapid migration potential to groundwater.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
