Registration Dossier
Registration Dossier
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EC number: 205-781-3 | CAS number: 151-05-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- The Freund’s Complete Adjuvant Test and the Open Epicutaneous Test
- Author:
- Klecak, G.
- Year:
- 1 985
- Bibliographic source:
- Current Problems in Dermatology
Materials and methods
- Principles of method if other than guideline:
- In an open epicutaneous test in 6–8 guinea pigs, 0.1 ml of 100, 30, 10, 3, 1, or 0.3% 1,1-dimethyl-2-phenylethyl acetate was applied daily for 3 weeks with the site uncovered. Suitable vehicles were suggested as ethanol, acetone, water, petrolatum, and/or PEG. Following induction, the animals were challenged on days 21 and 35 with 0.025 ml of 4% 1,1-dimethyl-2-phenylethyl acetate. The sites were scored 24, 48 and 72 h after exposure.
- GLP compliance:
- not specified
- Type of study:
- open epicutaneous test
Test material
- Reference substance name:
- α,α-dimethylphenethyl acetate
- EC Number:
- 205-781-3
- EC Name:
- α,α-dimethylphenethyl acetate
- Cas Number:
- 151-05-3
- Molecular formula:
- C12H16O2
- IUPAC Name:
- 1,1-dimethyl-2-phenylethyl acetate
- Test material form:
- solid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- A challenge concentration of 4% 1,1-dimethyl-2-phenylethyl acetate did not cause any reactions. 1,1-Dimethyl-2-phenylethyl acetate was not sensitizing to guinea pigs
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
