Registration Dossier
Registration Dossier
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EC number: 213-384-1 | CAS number: 941-98-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Basic toxicity of test chemical in rats and mice with cover letter dated 06/10/92
- Author:
- NTRL report
- Year:
- 1 992
- Bibliographic source:
- OTS0537531, 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin Sensitization potential of the test chemical was assessed on guinea pigs
- GLP compliance:
- not specified
- Type of study:
- other: standardized test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 1'-acetonaphthone
- EC Number:
- 213-384-1
- EC Name:
- 1'-acetonaphthone
- Cas Number:
- 941-98-0
- Molecular formula:
- C12H10O
- IUPAC Name:
- 1'-acetonaphthone
- Test material form:
- liquid
- Details on test material:
- -Name of test material: 1-(1-naphthyl)ethanone
- Molecular formula: C12H10O
- Molecular weight: 170.21 g/mol
- Smiles notation: c12c(cccc1C(C)=O)cccc2
- InChl: 1S/C12H10O/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-8H,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available.
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data available
- Vehicle:
- not specified
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- other: No data available.
- Vehicle:
- not specified
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 5 guinea pigs
- Details on study design:
- No data available.
- Challenge controls:
- No data available.
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- No sensitization was observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The test chemical was not sensitizing to the skin of any of the 5 Guinea Pigs. Therefore the test chemical was considered to be not sensitizing inGuinea Pigs.
- Executive summary:
Skin sensitization study was conducted on 5 Guinea Pigs for the test chemical. The test chemical was not sensitizing to the skin of any of the 5 Guinea Pigs. Therefore the test chemical was considered to be not sensitizing inGuinea Pigs.
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