Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report Date:
1970

Materials and methods

Principles of method if other than guideline:
Subjects exposed continuousy for six hours, and observed at intervals during that time. Observed daily over the subsequent 14 day observation period.
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
other: albinos of the CFY strain
Sex:
male/female
Details on test animals and environmental conditions:
Not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 360 min
Concentrations:
40 000 ppm v/v (i.e., 4%, the estimated vapour pressure concentration)
No. of animals per sex per dose:
5 male, 5 female
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 40 000 ppm
Based on:
test mat.
Exp. duration:
360 min
Mortality:
None
Clinical signs:
other: None
Body weight:
Transient weight loss in males, but by the end of the test was comparable with control.
Gross pathology:
None
Other findings:
None noted

Any other information on results incl. tables

"It is concluded that the samples of tested Perfluoro-1,3 -dimethylcyclohexane have no appreciable acute inhalation toxicity to the rat."

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
No inhalation toxicity at 4% v/v for this material.
Executive summary:

No inhalation toxicity at 4% v/v for this material.