1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: insufficient individual data reported

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Occupational Asthma caused by triglycidyl isocyanurate (TGIC).

Author:

Piirila, P., Estlander, T., Keskinen, H., Jolanki, R., Laakkonen, A., Pfaffli, P., Tupasela, O., Tuppurainen, M., Nordmann, H

Year:

1997

Bibliographic source:

). Clinical and Experimental Allergy 27, 510-514.

Report date:

1997

Materials and methods

Study type:

case report

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Investigation of a single case at the Finnish Institute of Occup. Health

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

EC Number:

219-514-3

EC Name:

1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Cas Number:

2451-62-9

Molecular formula:

C12H15N3O6

IUPAC Name:

tris[(oxiran-2-yl)methyl]-1,3,5-triazinane-2,4,6-trione

Details on test material:

no data available except that TGIC at 4% in a powder coating was concerned

Method

Type of population:

occupational

Ethical approval:

not specified

Subjects:

36-year old healthy non-smoking man working for 4 years as spray painter in a metal finishing company using TGIC- containing powder coatings (4% TGIC)

Clinical history:

He developed eczema on hands, face and body, and an occupational allergic eczema caused by TGIC. During weekends and vacation his skin reactions disappeared, but started again as soon as he resumed work.

Controls:

none

Route of administration:

dermal

Details on study design:

Patch tests were performed with paint, 10% and 3.2% in petrolatum, as well as 1%, 0.32% and 0.1% TGIC (>97%), which all gave strong positive reactions.

Results and discussion

Results of examinations:

Spirometry showed slight obstruction, blood eosinophiles and serum IgE was elevated, but skin pricks with common environmental allergens were negative. Respiratory challenge test with a powder coating containing 4% TGIC induced a dual reaction in PEF and late fall (23%) in FEV1, indicative of an occupational asthma.

Any other information on results incl. tables

Some doubts about the methodology remain.

Applicant's summary and conclusion

Conclusions:

It is concluded that TGIC is a contact allergen, and possibly a respiratory allergen.

Executive summary:

Single patient with allergic reactions to TGIC: Patch tests were performed with paint, 10% and 3.2% in petrolatum, as well as 1%, 0.32% and 0.1% TGIC (>97%), which all gave strong positive reactions. Spirometry showed slight obstruction, blood eosinophiles and serum IgE was elevated, but skin pricks with common environmental allergens were negative. Respiratory challenge test with a powder coating containing 4% TGIC induced a dual reaction in PEF and late  fall (23%) in FEV1, indicative of an occupational asthma. Some doubts about the methodology remain. It is concluded that TGIC is a contact allergen, and possibly a respiratory allergen.