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EC number: 205-793-9 | CAS number: 151-56-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP compliance and it does not follow a guideline, because the only stated endpoint is the renal papillary necrosis. Intravenous route.
Data source
Reference
- Reference Type:
- publication
- Title:
- PATTERN OF RENAL CORTICAL SCARRING AFTER EXPERIMENTAL PAPILLARY NECROSIS
- Author:
- WHITBOURN RJ, HENRY MA, TANG JD
- Year:
- 1 984
- Bibliographic source:
- Pathology (1984), 16, pp. 272-277.
Materials and methods
- Principles of method if other than guideline:
- Intravenous injection of ethyleneimine to assess the renal papillary necrosis.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: approx. 200 g
- Diet (e.g. ad libitum): pellet diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Rats were killed at 2 and 4 d, 1, 2, 4 and 8 wk and their kidneys were removed.
- Frequency of treatment:
- Once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg/kg bw
- No. of animals per sex per dose:
- 20 animals/group (6 groups)
- Control animals:
- not specified
Examinations
- Observations and examinations performed and frequency:
- Extent of renal papillary necrosis, at the sacrifice time, at 2 and 4 d, 1, 2, 4 and 8 wk .
Results and discussion
Results of examinations
- Clinical signs:
- not examined
- Mortality:
- not examined
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Renal papillary necrosis developed in all animals given ethylenimine. In most animals this was severe, and there was a tendency for the extent of the lesion to increase with time.
Applicant's summary and conclusion
- Conclusions:
- Ethyleneimine induces three types of renal cortical damage (papillary necrosis).
- Executive summary:
Three types of renal cortical damage were found in rats two months after papillary necrosis had been induced by ethyleneimine, at doses of 10 mg/kg bw, intravenous. Damage included: circumscribed areas of interstitial nephritis affecting either deep or superficial nephrons; wedge-shaped or conical scars, extending from capsule to inner medulla; widespread tubular dilatation and cyst formation with a diffuse increase in interstitial tissue, usually associated with dense fibrous repair of the papillary remnant.
In most animals the renal papillary necrosis was severe, and there was a tendency for the extent of the lesion to increase with time.
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