Registration Dossier

Administrative data

Description of key information

The acute toxicity data available for 1,3-dichloro-5,5-dimethylhydantoin are: LD50 rat oral = 542 mg/kg/bw, LD50 inhalation rat 1h = 20.5 g/m3 and LD50 dermal rabbit > 20000 mg/kg/bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
542 mg/kg bw
Quality of whole database:
Data reported by Health Council of the Netherlands in the document "Committee on Updating of Occupational Exposure Limits. 1,3-Dichloro-5,5-dimethylhydantoin, 2000/15OSH/046, 31 October 2002"

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
20 500 mg/m³
Quality of whole database:
Data reported by Health Council of the Netherlands in the document "Committee on Updating of Occupational Exposure Limits. 1,3-Dichloro-5,5-dimethylhydantoin, 2000/15OSH/046, 31 October 2002"

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
20 000 mg/kg bw
Quality of whole database:
Data reported by Health Council of the Netherlands in the document "Committee on Updating of Occupational Exposure Limits. 1,3-Dichloro-5,5-dimethylhydantoin, 2000/15OSH/046, 31 October 2002"

Additional information

Justification for classification or non-classification