Registration Dossier
Registration Dossier
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EC number: 613-793-9 | CAS number: 65429-29-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (15α)-3,17-Dioxoandrost-4-en-15-yl acetate
- EC Number:
- 613-793-9
- Cas Number:
- 65429-29-0
- Molecular formula:
- C21H28O4
- IUPAC Name:
- (15α)-3,17-Dioxoandrost-4-en-15-yl acetate
- Test material form:
- solid: crystalline
- Details on test material:
- Test item: acetoxy-adCas No.: 65429-29-0Batch No.: M64027NStorage: 15-30 °C, protected from light and wet
Constituent 1
Results and discussion
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Any other information on results incl. tables
| Software | Database / Method | Endpoint | Predicted value | |
| VegaNIC | Skin Sensitisation model (CAESAR) | Mutagenicity | No structural alerts were identified. | NON-mutagen |
| VegaNIC | Mutagenicity SarPy model | Mutagenicity | No structural alerts were identified. | NON-mutagen |
Applicant's summary and conclusion
- Conclusions:
- According to (Q)SAR modell: VegaNIC, the predicted values indicated that acetoxy-ad is not mutagen.
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