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EC number: 308-783-3
CAS number: 98510-75-9
reactions after induction
a dermal sensitisation study according to OECD TG 406, 1992 with
Undecylenamidopropyl Betaine (84% a.i.) in filter-sterilised tap
water, female Dunkin-Hartley guinea pigs were tested using the
Maximization test method. Positive control substance was
2-Mercaptobenzothiazole with a sensitisation rate of 90%.
the main experiment ten animals were treated intradermally with a 0.5%
(w/w) solution of the test substance in vehicle; for the dermal
induction a 35% (w/w) concentration of the test substance in vehicle was
used (= test group). Further five female animals were treated similarly
- with the exception that they received only the vehicle instead of the
test substance (= control group).
day 21 of the application period the challenge application was performed
on all control and test group animals. Duhring chambers with a 5% (w/w)
solution of the test substance in vehicle were used.
slight crust formation at the injection sides after intradermal
application with FCA no symptoms of systemic toxicity or other toxic
reactions were observed at any time during the study. Body weight development
of the animals was positive and within normal ranges.
the challenge no visible changes (no erythema and no edema) were
observed at any time point; i.e, there was no positive challenge result
in the test and the control group animals. Thus, the sensitisation rate
this study, Undecylenamidopropyl Betaine is not a dermal sensitiser.
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