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EC number: 308-783-3
CAS number: 98510-75-9
Table 1: Irritant/corrosive response data
for each animal at each observation time up to removal of each animal
from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Average 24h, 48h, 72h
Time for reversion (h)
*) Reversibility: c. = completely
reversible; n.c.= not completely reversible; n. = not reversible
a primary dermal irritation study according to EU Method B.4 (1992) and
OECD Guideline 404 (1992), 3 New Zealand White rabbits were
dermally patch (2.5 x 2.5 cm²) exposed for 4 hours to 0.5 g of Coco AAPB
(99.4 % dry solids) moistened with physiological saline. Test sites were
covered with semi-occlusive dressing.
Animals were then observed for 72 hours. Irritation was scored according
to Draize as stipulated in the OECD guideline.
30 to 60
minutes after patch removal, 3/3 animals showed well defined erythema
(score 2) and 1/3 animals each very slight edema (score 1) or slight
edema (score 2), 1/3 animals was free of edema at this observation. At
the 24 hours scoring, erythema had lessened in 2/3 animals to score 1
and worsened in 1/3 animal to score 3. At the 24 hours scoring 2/3
animals showed an edema score 1. The only skin reaction still present at
the 48 hours scoring, was a erythema score 2 in 1/3 animals. Fully
reversibility in all animals was reached for erythema at the 72 hours
scoring and for edema at the 48 hours scoring.
this study, Coco AAPB (99.4 % dry solids) is not a dermal
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