Registration Dossier
Registration Dossier
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EC number: 453-570-1 | CAS number: 540734-22-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Similar to OECD Guideline 203, GLP, key study, validity 2:
96h-LC50 = 13.1 mg/L (95% CL: 11.1 - 15.6 mg/L), based on nominal concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 13.1 mg/L
Additional information
One key study is available to assess the acute toxicity of the substance to zebra fish (Brachydanio rerio). This study was performed similar to OECD Guideline 203 with GLP statement. Based on the results of the preliminary test, the definitive test was conducted with the test concentrations of 5.0, 7.5, 11.2, 16.7 and 25.0 mg/L (nominal concentrations). Concurrent water control group was performed in parallel. The study was performed with a semi-static water renewal system.
The 96h LC50 was calculated as 13.1 mg/L (nominal concentration), and the 95% confidence limit was 11.1 mg/L - 15.6 mg/L. The highest concentration without observed effect was 5.0 mg/L.
All validity criteria of the OECD Guideline 203 were not fulfilled as no information is available on the analytical measurements. Based on the analytical measurements of the other aquatic studies (algae and aquatic invertebrates) and that this study was conducted in a semi-static system, there must be evidence that the concentration of the substance has been satisfactorily maintained. Therefore, this study is considered reliable with restrictions.
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