Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-313-2 | CAS number: 105-60-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Article in Russian. Only abstract available in English.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Occupational diseases of the skin in the production of Caprolactam.
- Author:
- Antoniev, A.A. & Gerasimow, B.S.
- Year:
- 1 971
- Bibliographic source:
- Klin. Med. 49, 116
- Reference Type:
- publication
- Title:
- Occupational diseases of the skin in the production of Caprolactam.
- Author:
- Antoniev, A.A. & Gerasimow, B.S.
- Year:
- 1 971
- Bibliographic source:
- Cited in: Henschler, D., (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (Nachtrag 1990), 1.-17. Lfg., Verlag Chemie (1991).
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Caprolactam
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 453
- Route of exposure:
- dermal
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
During investigations of the pH of the skin surface and function of perspiration, there were early functional and biochemical alterations of the skin. Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4). During investigation of the skin sensitivity to the test substance and other industrial allergens with the aid of drip skin tests 25.3% of persons had an increased sensitivity to the chemical. Limited imformation about the test substance.
Applicant's summary and conclusion
- Conclusions:
- Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4).
- Executive summary:
453 workers having occupational contact with the test substance and products of its synthesis were examined. During investigations of the pH of the skin surface and function of perspiration, there were early functional and biochemical alterations of the skin. Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4). During investigation of the skin sensitivity to the test substance and other industrial allergens with the aid of drip skin tests 25.3% of persons had an increased sensitivity to the chemical.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
