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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Old study, not fulfilling a guideline. No details on environmental conditions, test conditions, exposure concentrations and results.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
At the time of the study, no guideline was available. LD50 values were calculated using Thompson's method (1947) of moving averages and interpolation.
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-dichloroethylene
EC Number:
200-864-0
EC Name:
1,1-dichloroethylene
Cas Number:
75-35-4
Molecular formula:
C2H2Cl2
IUPAC Name:
1,1-dichloroethene
Details on test material:
- Name of test material (as cited in study report): Vinylidene chloride
- Source: Imperial Chemical Industries Limited, Mond Division, Runcorn, Cheshire
Before each experiment, stabilizer was removed by washing with alkali and water
- Purity: VDC was of analaR grade or of the next highest quality available

Test animals

Species:
mouse
Strain:
other: Alderley Park strain, specific pathogen-free
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: about 5 weeks old
- Weight at study initiation: 25 g
- Diet (e.g. ad libitum): standard pellet diet

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
No details
Doses:
5 concentrations
No. of animals per sex per dose:
5 groups of 6 mice (of each sex)
Details on study design:
No details
Statistics:
LD50 values were calculated respectively for male and female animals from Thompson's (1947) method of moving average and interpolation.

Results and discussion

Preliminary study:
Not applicable
Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
217 mg/kg bw
95% CL:
>= 201 - <= 235
Sex:
female
Dose descriptor:
LD50
Effect level:
194 mg/kg bw
95% CL:
>= 171 - <= 221
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
other: Data not used for classification; data obtained from rat studies are considered to be more robust and useful for the identification of the acute toxic hazard
Remarks:
Criteria used for interpretation of results: not specified
Conclusions:
Oral LD50 males = 217 mg/kg bw
Oral LD50 females = 194 mg/kg bw
Executive summary:

In an acute oral toxicity study, groups of 5 weeks old Alderley Park mice (6/sex) were given a single oral dose of vinylidene chloride in corn oil at 5 doses. Oral LD50: Males = 217 mg/kg bw (201-235); Females = 194 mg/kg bw (171-221)