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Ecotoxicological information

Toxicity to birds

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Link to relevant study record(s)

Description of key information

No data on toxicity of TPGDA to birds are available.

Key value for chemical safety assessment

Additional information

In Annex X Section 9.6.1 of Regulation (EC) No 1907/2006, it is laid down that any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level. In case of TPGDA, a mammalian dataset is available. In Annex XI Section 3, it is laid down that testing in accordance with sections 8.6 and 8.7 of Annex VIII and in accordance with Annex IX may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report (“Substance-Tailored Exposure-Driven Testing”). In accordance with Annex XI Section 3, it can be demonstrated in the risk assessment that the manufacture and the use of the substance do not pose an unacceptable risk for all environmental compartments as the risk characterization ratios (RCRs) of the chemical safety assessment are below 1 for all compartments (see Chemical Safety Report Ch. 10). In addition, if the log Koc and log Kow of the substance are below 3, a low adsorption potential is indicated. In case of TPGDA, the log Koc for the molecule is estimated to be in the range between 0.4 and 3 and thus indicates no potential for adsorption (see IUCLID Ch. 5.4.1). Based on the low log Kow and the low estimated BCF values, bioaccumulation in organisms is not to be expected (see IUCLID Ch. 5.3.1).  Hence, secondary poisoning is of no concern.   Therefore, and for reasons of animal welfare, no tests on birds are performed.