Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-254-7 | CAS number: 80-15-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Occlusive treatment of Albino rabbits, no further specification
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 0.10, 0.20, 2.0 ml/kg
- No. of animals per sex per dose:
- 2-4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.126 mL/kg bw
- 95% CL:
- 0.077 - 0.206
- Remarks on result:
- other: cooresponds to 133.6 mg/kg bw
Any other information on results incl. tables
Dose (ml/kg) |
Dead/dosed |
Days to death |
Skin irritation |
Signs and/or symptoms of toxicity |
2.0 |
2/2 |
0,1 |
necrosis |
Anaesthesia, eyes dark at 1 h |
0.20 |
4/4 |
1,1,2,2 |
necrosis |
Prostate at 1 day |
0.1 |
1/4 |
2 |
necrosis |
Very lethargic at 1 day |
Gross pathology of victims: lungs, livers and spleens congested; kidneys very dark; livers nottled; bladders filled with bloody urine; in survivors no remarkable findings
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
- Conclusions:
- Cumene hydroperoxide was highly toxic following acute covered dermal application
- Executive summary:
Cumene hydroperoxide was tested for acute dermal toxicity in rabbits (skin penetration); the LD50 was 0.126 ml/kg (cooresponds to 133.6 mg/kg bw); the signs of toxicity were anaesthesia, prostate and lethargy
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
