(7-methoxynaphthalen-1-yl)acetonitrile

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2004

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2005

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

and EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes (incl. QA statement)

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus-clone 5
- Source: Centre Technique du Bois et de l'Ameublement, Paris, France Breeder: CIT
- Age at study initiation (mean and range, SD): 6-24 hours
- Method of breeding: from parthenogenically reproducing brood female population
- Feeding during test animals were not fed during the test.


ACCLIMATION
- Acclimation period: from birth until use in the test
- Acclimation conditions (same as test or not): not
- Type and amount of food: Scenedesmus subspicatus, 0.1-0.2 mg of carbon / Daphnia / day

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Test conditions

Hardness:

289 mg CaCO3 / l

Test temperature:

18 - 22 °C not varying by more than 1°C throughout the test

pH:

6 - 9 and not varying by more than 1 unit in the solutions during the test

Dissolved oxygen:

≥ 60 % of the air saturation value

Salinity:

sum of Ca and Mg ions in the solution: 2.5 mmol / l ( molar ratio: Ca/Mg : 4:1, Na/K: 10:1)

Nominal and measured concentrations:

See the table below (any information on materials and methods icl. tables.

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

6.04 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

8.29 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Under our experimental conditions, the 48-hour EC50 in a static test system was 6.04 mg/L for Daphnia magna.