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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
13-Jun-2012 to 16-Jun-2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
not specified
Type of method:
column elution method
Water solubility:
< 0.05 mg/L
Temp.:
20 °C
Remarks on result:
other: pH value not provided

Results

 

Flow rate (ml/h)

Fraction No.

Stearyl Erucamide

pH value

25.0

1 (1-2)

< 0.05

6.4

 

2 (3-4)

< 0.05

6.3

 

3 (5-6)

< 0.05

6.3

 

4 (7-8)

< 0.05

6.3

 

5 (9-10)

< 0.05

6.3

 

6 (11-12)

< 0.05

6.2

 

7 (13-14)

< 0.05

6.3

 

8 (15-16)

< 0.05

6.3

 

 

 

 

12.5

1 (1-2)

< 0.05

6.0

 

2 (3-4)

< 0.05

6.1

 

3 (5-6)

< 0.05

6.2

 

4 (7-8)

< 0.05

6.2

 

5 (9-10)

< 0.05

6.1

 

6 (11-12)

< 0.05

6.1

 

7 (13-14)

< 0.05

6.1

 

8 (15-16)

< 0.05

6.2

 

 

Thus, the following value for water solubility of the test item Stearyl Erucamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).

 

Water solubility Stearyl Erucamide < 0.05mg/l

 

pH value HPLC water: 6.4

 

The water solubility was determined at 20°C.

Working range

The calibration curve fits over the whole working range from 0.05 to 2.05 mg/L with r2= 1. A quadratic fit was used.

 

Recovery

In the course of the recovery experiment, an average recovery rate of 99% was determined.

Conclusions:
Interpretation of results: insoluble (< 0.1 mg/L)
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
13-Nov-2012 to 14-Mar-2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
not specified
Type of method:
column elution method
Water solubility:
< 0.01 mg/L
Temp.:
20 °C
pH:
> 6 - < 8

Results

  

Flow rate (ml/h)

Fraction No.

Oleyl Palmitamide

pH value

25.0

1 (1-2)

< 0.01

6.7

 

2 (3-4)

< 0.01

6.7

 

3 (5-6)

< 0.01

6.8

 

4 (7-8)

< 0.01

6.8

 

5 (9-10)

< 0.01

6.8

 

6 (11-12)

< 0.01

6.8

 

7 (13-14)

< 0.01

6.8

 

8 (15-16)

< 0.01

6.8

 

 

 

 

12.5

1 (1-2)

< 0.01

6.7

 

2 (3-4)

< 0.01

6.7

 

3 (5-6)

< 0.01

6.7

 

4 (7-8)

< 0.01

6.7

 

5 (9-10)

< 0.01

6.7

 

6 (11-12)

< 0.01

6.7

 

7 (13-14)

< 0.01

6.7

 

8 (15-16)

< 0.01

6.7

 

 

Thus, the following value for water solubility of the test item Oleyl Palmitamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).

 

Water solubility Oleyl Palmitamide < 0.01mg/l

 

pH value HPLC water: 6.6

The water solubility was determined at 20°C

Working range

The calibration curve fits over the whole working range from 0.0 to 2.06 mg/L with r2= 1. A quadratic fit was used.

 

Recovery

In the course of the recovery experiment, an average recovery rate of 117% was determined.

Conclusions:
Interpretation of results: insoluble (< 0.1 mg/L)
Endpoint:
water solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Please refer to additional information field in the endpoint study summary (Water solubility)
Reason / purpose:
read-across source
Water solubility:
< 0.01 mg/L
Temp.:
20 °C
pH:
> 6 - < 8
Conclusions:
Interpretation of results: insoluble (< 0.1 mg/L)

Description of key information

< 0.01 mg/L at 20°C.

Key value for chemical safety assessment

Additional information

A water solubility value of < 0.05 mg/L at 20°C was determined according to EU Method A.6. Since the limit of detection was 0.05 mg/L, water solubility levels below 0.05 mg/L could not be determined from this study.

Using a revised version of the test method, a water solubility value of < 0.01 mg/L at 20°C was determined for an analogous substance (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6). Both substances are structurally similar, differing only by the number of carbon atoms in the alkyl chains. Since the molecular weight of (Z)-N-octadecyldocos-13-enamide is greater than that of olelyl palmitamide (590.06 compared to 505.90), it is reasonable to assume that the solubility of (Z)-N-octadecyldocos-13-enamide will be even lower than that of oleyl palmitamide. Therefore the solubility of (Z)-N-octadecyldocos-13-enamide is predicted to be < 0.01 mg/L at 20°C.