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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only short abstract; insufficient for assessment to few data available
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Range finding toxicity data: list V
Author:
Smyth, H.F.; Carpenter, C.P.; Weil, C.S.; Pozzani, U.C.
Year:
1954
Bibliographic source:
Arch Ind. Occup. Med. 10, 61-68

Materials and methods

Principles of method if other than guideline:
Penetration of rabbit skin is estimated by technique cessentially the one-day cuff method of Draize et al. (1944) using groups of four rabbits.
GLP compliance:
no
Remarks:
test conducted before the development of GLP
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorobutane
EC Number:
203-696-6
EC Name:
1-chlorobutane
Cas Number:
109-69-3
Molecular formula:
C4H9Cl
IUPAC Name:
1-chlorobutane

Test animals

Species:
rabbit
Strain:
other: New Zealand giant albino rabbits
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: trunk (fur was closely clipped over the entire trunk
- % coverage: 1/10 of body surface
- Type of wrap if used: impervious plastic film

REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: after 24 h contact, the film was removed



Duration of exposure:
24 h
Doses:
at least 20 mL/kg bw equivalent to 17600 mg/kg bw, calculated with a density of 0.88 g/cm³
No. of animals per sex per dose:
4 males; not clearly stated, if 4 males in total or 4 males per dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 17 600 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated on a density of 0.88 g/cm³

Applicant's summary and conclusion