Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.3; OECD 402 (1987)
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
water
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 400 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Clinical signs: piloerection, pallor, decreased motility, abdominal position, narrowed palpebral fissure and laboured breathing (2000, 400 mg/kg).
Gross pathology:
Effects on organs:
2000 mg/kg bw:

Females which died:

partial induration, black discoloration of the skin at the
treatment area, spotted liver.

Sacrificed males:

partial induration, skin detachment and brownish-black
discoloration of the skin.


400 mg/kg; females:

partial induration, skin detachment, brownish-red
discoloration of the skin, partly ecrustation.
Other findings:
Signs of toxicity (local):
Partial induration, encrustation and formation of scale,
partial detachment of the skin and black / red-brown
discolourations at the site of treatment (2000, 400 mg/kg).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU