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Registration Dossier
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EC number: 233-058-2 | CAS number: 10026-11-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: ZrCl4 is administered via the drinking water and under this condition, ZrCl4 is directly decomposed into ZrOCl2 and HCl. So during the experiment, the degradation products of ZrCl4 are ingested but not ZrCl4 itself.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicité et pharmacocinétique de l'oxychlorure de zirconium chez la souris et chez le rat
- Author:
- Delongeas J.L, Burnel D, Netter P, Grignon M, Mur J.M, Royer R.-J, Grignon G
- Year:
- 1 983
- Bibliographic source:
- J.Pharmacol., 1983, 14, 4, 437-447
Materials and methods
- Principles of method if other than guideline:
- Single oral dose administration
- GLP compliance:
- no
- Test type:
- other: Single oral dose administration
- Limit test:
- no
Test material
- Reference substance name:
- Zirconium tetrachloride
- EC Number:
- 233-058-2
- EC Name:
- Zirconium tetrachloride
- Cas Number:
- 10026-11-6
- Molecular formula:
- Cl4Zr
- IUPAC Name:
- zirconium tetrachloride
- Details on test material:
- Name of test material: Zirconium Chloride from Prolabo
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 20g +/-1 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Doses:
- No information but doses follow a geometric progression of 1.1.
- No. of animals per sex per dose:
- 24 total animals were used.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 438 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 412 - < 489
- Remarks on result:
- other: On the basis of the Bliss method
Any other information on results incl. tables
The rats died during the first 24 hours showed convulsions. The rats died after the first day and before the last day of observation showed inappetance, weight loss and prostration.
At certain concentrations, cerebral and pulmonary disorders are observed.
Post-mortem examination showed often intestinal necrosis and sometimes pulmonary necrosis.
Applicant's summary and conclusion
- Conclusions:
- Under the conditon of this study, the LD50 of ZrCl4 is 438 mg/kg bw. But ZrCl4 is administered via the drinking water and ZrCl4 is decomposed into ZrOCl2 and HCl. So during the experiment, the degradation products of ZrCl4 are ingested but not ZrCl4. This study is not relevant for ZrCl4.
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