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Short-term toxicity to fish

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Description of key information

The 96-hour LC50 was >1000 mg/l and is therefore considered to be non-toxic to fish at its limit of solubility.

Key value for chemical safety assessment

Additional information

Short term toxicity to fish studies have been conducted for Santicizer 261A but have not been available for review. A study using Rainbow trout was conducted by ABC Laboratories in 1980 and described in a 2006 American Chemistry Council report. There were sufficient details for an assessment to be made. The study reported an LC50 of >1000 mg/L and concluded that Santicizer 261A was non-toxic to Rainbow trout at its water solubility.

Two short term toxicity tests to fish were conducted using the very closely related phthalate Santicizer 278 (CAS RN: 16883 -83 -3), and were used as supporting studies for this endpoint. The reported 96-hour LC50 for Rainbow trout (Analytical Bio Chemistry Laboratories Inc, 1979) was >1000 mg/l (at 12°C), and for Fathead minnows (Analytical Bio Chemistry Laboratories Inc, 1979) also >1000 mg/l (at 22°C). In both tests the concentration used was 1000 mg/l. This concentration was determined by range finding tests to be appropriate as mortalities did not occur below this concentration

This concentration exceeds the solubility of the test compound (0.0015 mg/l at 25°C) but since no mortalities occurred even at this concentration, Santicizer 278 is considered non-toxic to fish at its limit of solubility. Due its structure and properties Santicizer 261A would be expected to give similar results.

 Santicizer 261A is therefore considered to be non-toxic to fish at its limit of solubility based on experimental data, read-across and calculated data.