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In a short-term toxicity test to Rainbow trout, ABC Laboratories (Analytical Bio Chemistry Labs, Inc, 1980) reported a 96 -hour LC50 of >1000 mg/L, indicating that S261A is non-toxic to fish.


Further ecotoxicological data is available for Santicizer 278 (S278) (CASRN 16883-83-3) - structurally the most closely related phthalate to Santicizer 261A, being the only other higher molecular weight phthalate to have an additional benzyl group. These two phthalates also have similar alkyl chain lengths and demonstrate similar physico-chemical properties to each other (as they do to other higher molecular weight phthalates - see Section 4). We therefore consider it appropriate to read across from Santicizer 278 to Santicizer 261A for ecotoxicological effects, as we would expect the two substances to behave very similarly and exert similar effects on aquatic organisms.


In short-term toxicity tests to fish using Santicizer 278, Analytical Bio Chemistry Labs, Inc (1979a,b) reported 96-hour LC50s of >1000 mg/l for both Rainbow trout and Fathead minnows. In a toxicity test to aquatic algae (EG&G, Bionomics Marine Research Laboratory, 1979), the 96-hour EC50 based on both cell number decrease and growth rate was >1000 mg/l. In both the fish tests and the algae test Santicizer 278 was found to be non-toxic, and the extremely close structural relationship between Santicizer 278 and Santicizer 261A means that we would not expect Santicizer 261A to be toxic to aquatic organisms.

Acute invertebrate data is available for Santicizer 261A (ABC Labs, 1979) and is supported by use of a QSAR (ECOSAR, USEPA, 2008), of which Santicizer 261A is in the model's domain. Both indicate that Saniticizer 261A does not cause effects at the limit of solubility to daphnids.