Registration Dossier
Registration Dossier
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EC number: 208-859-5 | CAS number: 544-10-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, only short communication
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of 10 aliphatic halogenated hydrocarbons in the mouse bone marrow micronucleus test
- Author:
- Crebelli, R. et al.
- Year:
- 1 999
- Bibliographic source:
- Mutagenesis, 14, 207-215
Materials and methods
- Principles of method if other than guideline:
- OECD 474
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chlorohexane
- EC Number:
- 208-859-5
- EC Name:
- 1-chlorohexane
- Cas Number:
- 544-10-5
- Molecular formula:
- C6H13Cl
- IUPAC Name:
- 1-chlorohexane
- Details on test material:
- purity 99 % (from Aldrich)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: olive oil
- Doses:
- no data
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 325 mg/kg bw
- Clinical signs:
- piloerection, hypoactivity, hunched posture, sedation, shallow breathing (Tab. II)
Applicant's summary and conclusion
- Conclusions:
- The LD50 for the intraperitoneal route resulted in 1325 mg/kg bw for male and female rats.
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