Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, only short communication

Data source

Reference
Reference Type:
publication
Title:
Evaluation of 10 aliphatic halogenated hydrocarbons in the mouse bone marrow micronucleus test
Author:
Crebelli, R. et al.
Year:
1999
Bibliographic source:
Mutagenesis, 14, 207-215

Materials and methods

Principles of method if other than guideline:
OECD 474
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorohexane
EC Number:
208-859-5
EC Name:
1-chlorohexane
Cas Number:
544-10-5
Molecular formula:
C6H13Cl
IUPAC Name:
1-chlorohexane
Details on test material:
purity 99 % (from Aldrich)

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: olive oil
Doses:
no data
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 325 mg/kg bw
Clinical signs:
piloerection, hypoactivity, hunched posture, sedation,  shallow breathing (Tab. II)

Applicant's summary and conclusion

Conclusions:
The LD50 for the intraperitoneal route resulted in 1325 mg/kg bw for male and female rats.