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Registration Dossier
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EC number: 219-094-1 | CAS number: 2356-53-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 July 1987 to 13 August 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- EC Number:
- 219-094-1
- EC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Cas Number:
- 2356-53-8
- Molecular formula:
- C3Cl2F6O
- IUPAC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Reference substance name:
- Methylic Adduct
- IUPAC Name:
- Methylic Adduct
- Details on test material:
- - Name of test material (as cited in study report): Ethane,1,2-dichloro-1,1,2-trifluoro-2-trifluoromethoxy
- Substance type: pure substance
- Physical state: liquid
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: F104206
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: in the dark under ambient conditions.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- one single instillation (0.1 ml)
- Observation period (in vivo):
- 1, 24, 48, 72 hours.
- Number of animals or in vitro replicates:
- 3 (2 males + 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Conjunctival Discharge
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
In all animals, at all time points, no irritant responses were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No irritant responses were noted.
It was concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is practically non-irritant to rabbit eyes - Executive summary:
The IRI project No.238237, includes an acute oral toxicity test, an eye irritation test and a dermal irritation test.
In the acute eye irritation test, three rabbits were treated with a single instillation of 0.1 ml of the test item.
The eyes were examined for irritation, using standard illumination, at 1, 24, 48 and 72 hours after instillation, using scoring system.
No corneal, iridial or conjunctival responses were noted.
It is concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is non-irritant to rabbit eyes.
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