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EC number: 212-161-6
CAS number: 766-09-6
After the first induction with 6% test item
formulation 6 of 20 animals of the test item group showed severe skin
effects (grey-black hardened area with red surrounding on the treatment
area, size up to 1 * 0.5 cm, like corroded) and 2 of 20 animals revealed
skin redness (grade 1). There were no skin effects in the animal of the
After the second and third induction with 3%
test item formulation no skin effects in the animals of the test item
group and control group were observed.
The 1st induction was carried out on the
left flank with 6% test item formulation, the 2nd and 3rd induction on
the right flank with 3% test item concentration because of the strong
skin effects mentioned after the 1st induction.
The skin effects mentioned were most
probably due to corrosive properties of the test item.
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