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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
(only one test concentration)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-ethylpiperidine
EC Number:
212-161-6
EC Name:
1-ethylpiperidine
Cas Number:
766-09-6
Molecular formula:
C7H15N
IUPAC Name:
1-ethylpiperidine
Details on test material:
- Name of test material (as cited in study report): 1-Ethylpiperidin
- Physical state: liquid
- Analytical purity: > 98 %

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: M. GAUKLER, Offenbach; Germany
- Mean weight at study initiation: males: 2.4 kg; females: 2.5 kg
- Diet: Ssniff K, Standard diet for rabbits and guinea pigs, INTERMAST GmbH, Soest, Germany, ad libitum
- Water: water, ad libitum

ENVIRONMENTAL CONDITIONS
- no data


Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: the clipped skin of the back and flanks; clipping of the dorsal and lateral parts of the trunk was performed ca 15 to 24 hours before treatment.
- Application area: approx. 50 cm²
- Type of wrap if used: inert foil, fixed with a adhesive tape.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with warm water or a water:lutrol mixture and dried with cellulose
- Time after start of exposure: 24 hrs

Duration of exposure:
24 h
Doses:
200 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: Check for dead or moribund animals was performed within 1, 24 and 48 hours and within 8 days. Clinical signs of intoxication were recorded on working days.
- Necropsy of survivors performed: yes, animals were sacrificed with CO2
- Other examinations performed: clinical signs, local irritating skin findings

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality (0/10 animals died).
Mortality:
0/5 males and 0/5 females died.
Clinical signs:
other: No systemic toxicity observed. 24 hours after application all animals showed irritation and formation of necrosis, not reversible at the end of the observation period.
Gross pathology:
Sacrificed animals: no substance-related findings.

Applicant's summary and conclusion