Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1-dimethoxytrimethylamine
- EC Number:
- 225-063-3
- EC Name:
- 1,1-dimethoxytrimethylamine
- Cas Number:
- 4637-24-5
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 1,1-dimethoxy-N,N-dimethylmethanamine
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
Dimethylformamid-dimethylacetal, no further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- single application to the conjunctival sac of the right eyelid
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 0.9
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Conclusions:
- The test item causes irreversible damage to eyes in rabbits.
- Executive summary:
The test substance causes irreversible damage to the eyes of rabbits.
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