Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Endpoint summary
Administrative data
Description of key information
skin irritation: The substance is slightly irritating to the skin.
eye irritation: In an eye irritation study with rabbits the test substance has been shown to cause irreversible damage to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
skin irritation
The skin irritating potential of the test substance was examined in an in vivo study with 3 rabbits. The single application of the substance to the skin of the animals caused slight up to well-defined redness and very slight edema within 72 hrs after application. In accordance with 67/548/EEC, the test item needs to be classified as skin irritating, but according to the GHS classification the test item has not to be classified. [BASF, 1984]
eye irritation
The eye irritating potential of the test substance was examined in an in vivo study with 3 rabbits. The single application of the substance to the conjunctival sac of the right eyelid of the animals caused well-defined redness and slight up to well-defined chemosis of the conjunctiva
within 72 hrs after application. Furthermore, the substance caused a cornea opacity which was not reversible within 8 days and showed no effects on the iris. [BASF, 1984]Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Classification for skin irritation is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008, but according to EU Directive 67/548/EEC 1,1-dimethoxytrimethylamine needs to be classified as skin irritating (R38).
1,1-Dimethoxytrimethylamine is considered to be eye irritating (EU: R41; GHS: cat.1 H318) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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