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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: testicular observation (after ingestion of capsules)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1995
Reference Type:
review article or handbook
Title:
1934b. Di-nitrophenol. Studies of blood, urine, and tissues of dogs on continued medication and after acute fatal poisoning.
Author:
Tainter ML, Cutting WC, Wood DA, et al.
Year:
1934
Bibliographic source:
Arch Pathol 18:881.

Materials and methods

Principles of method if other than guideline:
The method was based on an exposure to dogs via capsules of 2,4-dinitrophenol for six months. No further details were specified.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dinitrophenol
EC Number:
200-087-7
EC Name:
2,4-dinitrophenol
Cas Number:
51-28-5
Molecular formula:
C6H4N2O5
IUPAC Name:
2,4-dinitrophenol

Test animals

Species:
other: dog
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: capsules
Duration of treatment / exposure:
six months
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
5 mg/kg/day
Basis:
other: in capsules
Remarks:
Doses / Concentrations:
10 mg/Kg/day
Basis:
other: in capsules
No. of animals per sex per dose:
3 per dose group

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEL
Effect level:
10 other: capsules
Sex:
male
Remarks on result:
other: no futher information available

Results: F1 generation

Effect levels (F1)

Remarks on result:
not measured/tested

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.

Applicant's summary and conclusion

Conclusions:
No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.
Executive summary:

Data have been obtained from secondary source that mentions Tainter ML, Cutting WC, Wood DA, et al. 1934b. Di-nitrophenol. Studies of blood, urine, and tissues of dogs on continued medication and after acute fatal poisoning. Arch Pathol 18:881. The method was based on an exposure to dogs via capsules of 2,4-dinitrophenol for six months. No further details were specified.

Testicular tissue vas histologically analysed after the 2,4 -dinitrophenol exposure and no gross histological evidence of treatment-related testicular damage. No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.