Registration Dossier
Registration Dossier
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EC number: 700-230-8 | CAS number: 3160-86-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
No acute or chronic aquatic toxicity data are available for the PA6T salt [1,4-benenedioic acid, compound with hexane-1,6-diamine (1:1)]. Available acute data for the PA66 salt [adipic acid, compound with hexane-1,6-diamine (1:1); CAS# 3323-53-3; EC# 222-037-3] indicates that the 96-hour LC50 in Lepomis macrochirus is 470 mg/L; the 48-hour EC50 in Daphnia is 90 mg/L; and the 72-hour EC50 in Scenedesmus subspicatus is 538 mg/L. Since daphnids appear to be the most sensitive species to these component chemicals, the calculated EC50 for daphnids is:
1/EC50 combined = 0.5/23 ppm (HMDA EC50) + 0.5/1000 ppm (terephthalic acid EC50) = 1/0.022 = 49 ppm
This value is consistent with the measured EC50 of 90 ppm in daphnids with PA66 salt, but this was tested as a 50% solution. Although terephthalic acid has a lower acute toxicity to daphnids of >1000 mg/L than adipic acid, EC50 = 85 mg/L, the lower toxicity expected with terephthalic acid does not materially impact the EC50 relative to HMDA.
Available chronic data for the PA66 salt indicates that the NOEC from a 21-day chronic toxicity study with Daphnia ranges from 4.2-6.3 mg/L. All component compounds are considered to be readily biodegraded. No log Kow data exists for PA6T salt, but the component substances have log Kow value all<3.
References:
OECD SIDS (2004). OECD SIDS Dossier for Adipic Acid (CAS 124-04-9) (http://www.inchem.org/documents/sids/sids/124049.pdf).
OECD SIDS (2001). OECD SIDS Dossier for Terephthalic Acid (CAS 100-21-0) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/100-21-0.pdf).
OECD SIDS (nd). OECD SIDS Dossier for Hexamethylenediamine (CAS 124-09-4) (http://www.inchem.org/documents/sids/sids/124094.pdf).
OECD SIDS (2003). OECD SIDS for Adipic Acid, Compound with Hexane-1,6-diamine (1:1) (CAS 3323-53-3) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/3323533.pdf).
BASF (2014). Material Safety Data Sheet, AH-salt solution (http://www.plasticsportal.net/wa/EU/Catalog/ePlastics/doc4/BASF/PRD/30214804/.pdf?title=&asset_type=msds/pdf&language=EN&validArea=REG_EU&urn=urn:documentum:ProductBase_EU:09007af88001a52c.pdf).
Conclusion on classification
Based on data from component chemicals and similar salts, the calculated EC50 in Daphnia (the most sensitive species) is 49 ppm. In addition, 21-day NOEC in Daphnia with a similar salt was ~5 ppm. All component compounds are considered readily biodegraded, and all component substances have log Kow values <3. Therefore the test substance is not classified for acute or chronic aquatic toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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