Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-050-0
CAS number: 91-21-4
The 48 -h EC50 value is 25.9 mg/L (nominal) in aquatic invertebrates (Daphnia magna).
The toxicity of 1,2,3,4 -tetrahydroisoquinoline to aquatic invertebrates
was examined in a GLP-compliant study according to OECD guideline 202.
In this study, Daphnia magna (4 replicates of 5 animals per
concentration) were exposed to nominal concentrations of 6.25, 12.5, 25,
50 and 100 mg/L and a blank control for 48 hours. Nominal concentrations
were analytically verified at the start and at the end of the test. As
test substance recoveries ranged from 90 -102%, effect concentrations
are expressed as nominal. At the start of the test and after 24 and 48
hours each test vessel was visually checked for immobilised daphnids. In
addition any abnormal behaviour or appearance was documented. After 48
hours no immobilisation was noted at the lowest test concentration of
6.25 mg/L. At test concentrations of 12.5 and 25 mg/L immobilisation was
observed in 17/20 and 15/20 daphnids, respectively. At the highest test
concentrations of 50 and 100 mg/L all animals were immobile. No
additional adverse effects or abnormal behaviour were observed in any of
the test treatments. Based on these findings, the 48 -h EC50 value is
determined at 25.9 mg/L (nominal).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again