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EC number: 202-050-0
CAS number: 91-21-4
1,2,3,4 -tetrahydroisoquinoline is characterised as not readily biodegradable.
The biodegradability of 1,2,3,4 -tetrahydroisoquinoline was determined
in a GLP-compliant study according to OECD guideline 301A (DOC Die-Away
test). In this study, flasks containing test substance in a
concentration of about 20 mg/L Dissolved Organic Carbon and inoculum
from a municipal treatment plant in a mineral medium, and two blank
controls (only mineral medium and inoculum) were incubated for 28 days.
Dissolved Organic Carbon (DOC) measurements were performed twice per
week and DOC-values compared with the values at the start of exposure.
The decrease of DOC concentration is expressed as biodegradation degree.
After 28 -days exposure, less than 10% biodegradation of the test
substance was observed. Results with the reference substance aniline
showed that the test system was sufficiently sensitive. Based on these
findings 1,2,3,4 -tetrahydroisoquinoline is characterised as not readily
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