Registration Dossier

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Administrative data

Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: other: calculation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Validated QSAR System - Substance is in domain of the system

Data source

Reference
Reference Type:
other: QSAR
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A quantitative structure-activity relationship (QSAR) system for the estimation of the mutagenic potency in S. typhimurium that incorporates S9 metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with DNA. A chemically divers training set was used for which Ames mutagenicity data is available.
GLP compliance:
no
Type of assay:
other: Calculation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The QSAR program calculated a negative mutagenic potential of the test substance in bacteria.

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Applicant's summary and conclusion