α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol

PBT assessment

PBT assessment: overall result

Reference

Name:

α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol

Type of composition:

boundary composition of the substance

State / form:

solid: particulate/powder

Reference substance:

α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol

PBT status:

the substance is not PBT / vPvB

Justification:

Classification of a,a-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol for effects in the environment:

 

The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for a,a-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1- methanol. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.

 

Persistence assessment

The tested substance fulfils the P criterion within Annex XIII based on the assessment that here follows:

 

Biotic degradation

In a prediction done using the Estimation Programs Interface Suite, the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms was predicted. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.

 

Experimental results from the read across substances also indicate that they are not readily biodegradable.

 

Thus, based on the above available information, it has been concluded that chemical a,a-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1- methanolis likely to be persistent in nature.

 

Bioaccumulation assessment

The tested substance fulfils the B criterion within Annex XIII based on the assessment that here follows:

 

Theestimated BCF value from authoritative database was determined to be in the range 62.2 to 291000, respectively and the octanol water partition coefficient of the test chemical was determined to be 7.114±0.001 at 25°C as per OECD TG 117, respectively, which is greater than the threshold of 4.5.If this chemical is released into the aquatic environment, there should be a high risk for the chemical to bioaccumulate in fish and food chains.

 

Thus, based on the available information, chemical a,a-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol is likely to be bioaccumulative (B) in nature.

 

Toxicity assessment

The tested substance does not fulfil the T criterion within Annex XIII based on the assessment that here follows:

 

Mammals

The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1(oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).

 

Aquatic organisms

In accordance with Annex VII Column 2, the study is scientifically not necessary and does not need to be conducted as the substance is highly insoluble in water, hence indicating aquatic toxicity is unlikely to occur.

 

There are no available long-term toxicity evaluations for a,a-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol (CAS no. 6786-83-1). By speculation, long-term NOEC for aquatic organisms were not expected for the substance at concentration below 0.01 mg/L based on the data mentioned above

 

The chemical was therefore not considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.

 

Conclusion

Based on critical, independent and collective evaluation of information summarized herein, the tested compound fulfils the P and B criterion, but does not fulfil the T criterion and has therefore not been classified as a PBT compound within Annex XIII.