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EC number: 812-925-4 | CAS number: 1639345-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 21, 2016 - March 23, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 13. Apr. 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- EC Number:
- 812-925-4
- Cas Number:
- 1639345-42-8
- Molecular formula:
- C6H12FNSi
- IUPAC Name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The water-accommodated fractions (WAFs) were prepared for the test. This was done by weighing the nominal loads 4.6 / 10 / 22 / 46 / 100 mg/L (real load 4.6 / 10.2 / 22.3 / 46.0 / 100.7 mg/L) adding the corresponding amount of dilution water and shaking vigorously for 24 hours. The resulting solution was filtrated through 0.45 μm nylon filters.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
-Species: Daphnia magna
-Variety: STRAUS
-Strain: Berlin
-Sex: female
-Age: between 0 and 24 hours
-Origin: Umweltbundesamt Berlin
-In-house breeding since: 27. September 2007
Husbandry
Daphnia magna is bred in the LAUS GmbH throughout the year. The animals are kept for the use in toxicity tests. They multiply by parthenogenesis, thus being genetically identical.
The husbandry is performed similar to the method described in the OECD guideline, following SOP 115 002 01 („Zucht und Hälterung von Daphnia magna STRAUS“), Version 12
from 02. Feb. 2015.
-Vessels: preserving glasses, nominal volume 2 L
-Medium: M4-Medium (recipe of ELENDT)
-Food: unicellular green algae (Desmodesmus subspicatus)
- Medium renewal: twice a week
- Photo period: 16/8 hours, using neon tubes
-Temperature: 20 +/-2 °C
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 in mg CaCO3/L
- Test temperature:
- 19.1 – 21.0 °C
- pH:
- 6.4 - 7.9
- Dissolved oxygen:
- The lowest concentration of dissolved oxygen at the end of the test was 8.8 mg/L
- Salinity:
- not applicable
- Conductivity:
- not given in the report
- Nominal and measured concentrations:
- The measured concentrations were in a range of 89 % - 110 % of the nominal concentration. Therefore, the determination of the results was based on the mean of the nominal concentrations.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: Beakers, glass, nominal volume 50 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Deionised water with an enrichment of certain minerals (dilution water as demanded in the guidelines) was used in the test.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
EFFECT PARAMETERS MEASURED: Mobility after 24 and 48 h.
TEST CONCENTRATIONS
- concentrations applied: 4.6 / 10 / 22 / 46 / 100 mg/L (nominal concentrations) - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but eyposure is to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0
- Results with reference substance (positive control):
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a current reference study. The 24h-EC50 value was determined as 1.7 mg/L, lying within the demanded range of 0.6 – 2.2 mg/L stated in the guideline.
- Reported statistics and error estimates:
- There were no toxic effects observed in the test and therefore statistical analysis of the results was not required.
Any other information on results incl. tables
Table 1 Calculated Test item Concentrations
Nominal Concentration Test Item
|
Calculated Concentration Test Item t = 0 h
|
Calculated Concentration Test Item t = 48 h
|
% of Nominal concentration t = 0 h
|
% of Nominal concentration t = 48 h
|
mg/L |
mg/L |
mg/L |
% |
% |
Blank control |
-- |
-- |
-- |
-- |
4.6 |
4.9 |
4.1 |
106 |
89 |
10 |
9.4 |
10.5 |
94 |
105 |
22 |
21.7 |
23.4 |
99 |
106 |
46 |
46.0 |
49.6 |
100 |
108 |
100 |
101.6 |
110.1 |
102 |
110 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-hour EC50 value of >100 mg/L and a NOEC of ≥100 mg/L have been determined for the effects of the test substance on mobility of Daphnia magna based on nominal exposure concentrations of the substance. The test substance hydrolyses in water and it is therefore likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
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